This move was widely expected as the drugmaker's biggest shareholder signalled it wanted a leadership change.
(READ MORE: Bidvest & PIC bully Adcock's board)
Jonathan Louw, who had been at helm since 2008, will step down with immediate effect.
(WATCH VIDEO: Corporate Governance & the rights of minority shareholders)
Louw is the latest top official to step down at [DATA AIP:Adcock Ingram Holdings LTD.] after the firm's biggest shareholder, Bidvest Group, helped oust Chairman Khotso Mokhele in February.