Zuma had the support of the African National Congress (ANC), which controls almost two-thirds of the assembly. He won with 225 lawmakers voting against the no-confidence motion. Ninety-nine voted in favour and 22 abstained, a result that mirrored his victory last March. Zuma did not attend the proceedings.
Nedbank reported an 8.5 percent rise in annual profit on Wednesday, meeting estimates, as growth in fee income offset muted growth in lending.
Low growth, a currency under pressure and the risk of credit downgrade worrying investors.
Mujuru was Mugabe's deputy for a decade and seen as the veteran president's likely successor until he fired her in 2014.
Disappointing economic growth in South Africa at the end of 2015 is likely to heighten fears its credit rating will be cut to "junk".